Author

Louis DeFalco

Agency for Science, Technology and ResearchORCID 0000-0003-1874-1838Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:long-read sequencing· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

Roland G. HuberiD· 3 shared Andres MeritsiD· 2 shared Kiat Yee Tan· 2 shared Siwy Ling YangiD· 2 shared Su Ying Lim· 2 shared Yue WaniD· 2 shared Alexander LezhavaiD· 1 shared Chaitanya Kumar JaladankiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Roland G. HuberORCID

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3 papers

Recent·Most cited

BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedMay 12, 2026

Evaluating Molecular Docking Programs for RNA-Targeted Ligand Screening: Influence of Binding Modes and Ligand Types

Kai‐Chen Wang, Louis DeFalco, Chaitanya Kumar Jaladanki…·Hao Fan

This study evaluates three docking programs for RNA-ligand screening, finding similar overall performance but differences across RNA classes and chemotypes, suggesting tailored scoring strategies could improve virtual screening.

1 citation

protein structurestatistical model

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GenomicsNature CommunicationsPeer-reviewedSep 26, 2025

A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation

Siwy Ling Yang, Louis DeFalco, Sainan Wang…·Yue Wan

2 citations

viruslong-read sequencing

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GenomicsNature CommunicationsPeer-reviewedAug 25, 2021

Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions

Siwy Ling Yang, Louis DeFalco, D. H. Anderson…·Yue Wan

This study maps SARS-CoV-2 RNA interactions in vivo, identifying structural elements and host RNA interactions that may contribute to viral pathogenicity.

DOI 10.1038/s41467-021-25357-1

long-read sequencingexperimental assay

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