Localization-dependent activation of the DEAD-box ATPase Vasa by eLOTUS domains
Asen Garbelyanski, David Hauser, Alberto Trolese, Prateek Kumar, Hin Hark Gan, Caroline De Almeida, Matthias P. Mayer, Maria Hondele, Teresa Carlomagno, Kristin C. Gunsalus, Mandy Jeske
This study identifies how eLOTUS domains activate Vasa by promoting its RNA and ATP binding through a charged disordered sequence, revealing a localization-dependent regulatory mechanism.
bioRxiv · Mar 29, 2026 · PreprintBiochemistry