Author

Mandy Jeske

Heidelberg UniversityORCID 0000-0002-1107-9442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 4 Assay:protein structure· 4 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Asen GarbelyanskiiD· 2 shared David HauseriD· 2 shared Harpreet Kaur SalganiaiD· 2 shared Peter Refsing AnderseniD· 2 shared Alberto TroleseiD· 1 shared Anja EbertiD· 1 shared Astrid BruckmanniD· 1 shared Caroline De AlmeidaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Asen GarbelyanskiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Localization-dependent activation of the DEAD-box ATPase Vasa by eLOTUS domains

Asen Garbelyanski, David Hauser, Alberto Trolese, Prateek Kumar, Hin Hark Gan, Caroline De Almeida, Matthias P. Mayer, Maria Hondele, Teresa Carlomagno, Kristin C. Gunsalus, Mandy Jeske

This study identifies how eLOTUS domains activate Vasa by promoting its RNA and ATP binding through a charged disordered sequence, revealing a localization-dependent regulatory mechanism.

bioRxiv · Mar 29, 2026 · PreprintBiochemistry

Probing direct interactions between nuclear proteins in cells with nxReLo

Sherif Ismail, Jana Kubíková, Maria Maichel, Peter Refsing Andersen, Mandy Jeske

The paper introduces nxReLo, a cell culture-based assay to identify nuclear protein interactions, and applies it to study the RDC complex in Drosophila, combining it with AlphaFold for structural insights.

Proceedings of the National Academy of Sciences · Nov 26, 2025Peer-reviewedBiochemistry

Molecular insight into the Drosophila piRNA pathway network through a combination of systematic protein interaction screening and structural prediction

Harpreet Kaur Salgania, Jutta Metz, Eric Lingren, Christian Bleischwitz, David Hauser, Katalin Oliveras Máté, Daniel Bollack, Felix Lahr, Astrid Bruckmann, Asen Garbelyanski, Mandy Jeske

The paper identifies six protein complexes in the Drosophila piRNA pathway through protein interaction screening and structural modeling.

Nucleic Acids Research · Oct 14, 2025Peer-reviewedBiochemistry

Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway

Sebastian Riedelbauch, Sarah Masser, Sandra Fasching, Sung-Ya Lin, Harpreet Kaur Salgania, Mie Aarup, Anja Ebert, Mandy Jeske, Mia T Levine, Ulrich Stelzl, Peter Refsing Andersen

The paper studies the evolution of protein interactions in the Drosophila piRNA pathway, revealing conserved and co-evolved interactions that support evolutionary adaptation.

bioRxiv · Oct 5, 2024 · PreprintMolecular Biology