A generalizable system for antigenic peptide targeting across HLA-I allotypes
Wyatt Blackson, Ean L. Small, Shirley M. Sun, Omkar Shinde, Ram Pantula, Sean J. Wang, Photis Rotsides, Haotian Du, Yi Sun, Daniel Hwang, Chloe S. Wang, Tianyu Lu, Eli Laskawy, Richa Kapoor, Muzamil Yaqub Want, , Nikolaos G. Sgourakis
The paper develops a system to create binders compatible across HLA allotypes, validated against clinically relevant antigens and demonstrated in CAR T cells.
bioRxiv · May 22, 2026 · PreprintSynthetic Biology