Daniel Hwang

Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

A generalizable system for antigenic peptide targeting across HLA-I allotypes

The paper develops a system to create binders compatible across HLA allotypes, validated against clinically relevant antigens and demonstrated in CAR T cells.

CD11c+ CD8 T cells cause IFN-g-dependent autoimmune neuroinflammation that is restrained by PD-1 signaling.

This study develops a CD8 T cell-dependent model of MS and identifies differences in brain and spinal cord inflammation, showing that IFN-g and PD-1 signaling regulate CD8 T cell-mediated neuroinflammation.

CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreading

The paper determines the cryo-EM structure of an MHC-I/TAPBPR peptide intermediate, revealing how antigen proofreading occurs through transient peptide interactions.

Regulating IL-2 immune signaling function via a core allosteric structural network

This paper investigates how dynamic structural networks in IL-2 superkines affect receptor binding and signaling, showing that modulating core dynamics can improve immune cell selectivity.