Nikolaos G. Sgourakis

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

The paper develops a system to create binders compatible across HLA allotypes, validated against clinically relevant antigens and demonstrated in CAR T cells.

This paper develops a stabilized MR1 variant, SMART-MR1, that preserves native-like ligand presentation and TCR recognition while enabling biochemical and structural studies.

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

The paper determines the cryo-EM structure of an MHC-I/TAPBPR peptide intermediate, revealing how antigen proofreading occurs through transient peptide interactions.

The paper predicts MHC-I restriction of T cell receptors for public antigens using structural analysis of TCR:pHLA complexes.

This paper investigates how dynamic structural networks in IL-2 superkines affect receptor binding and signaling, showing that modulating core dynamics can improve immune cell selectivity.

This paper introduces HLA3DB, a curated database of peptide/HLA complexes, and presents RepPred, a method for predicting T cell epitope structures with improved accuracy.