Cancer BiologybioRxivPreprint
Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signaling
Jovana Rajak, Ke Meng, Anna Lena Stippel…·Miriam Erlacher
This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.
DOI 10.1101/2025.10.01.679664