Miriam Erlacher

Hierarchical classification of hematologic malignancies using epigenetic and genetic information

The paper develops a hierarchical classification framework combining epigenetic and genetic data with machine learning to improve diagnosis and risk stratification in hematologic malignancies.

TET2 loss promotes premalignant survival and clonal selection in MYC-driven B cell lymphoma

This study shows that TET2 loss increases lymphoma penetrance and promotes survival of premalignant B cells in MYC-driven lymphoma by reducing apoptosis.

Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signaling

This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.

AURKA promotes malignant properties of neuroblastoma and is downregulated by the PP2A pathway

This study shows AURKA promotes neuroblastoma malignancy and is suppressed by the PP2A pathway, with AURKA cooperating with MYCN in tumor progression.

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

Checkpoint kinase 1 is essential for fetal haematopoiesis and hematopoietic stem cell survival

This study shows that CHK1 is essential for hematopoietic stem cell survival and fetal hematopoiesis, and that its inhibition causes severe DNA damage and prevents HSC expansion.