Author

Christian Flotho

University of FreiburgORCID 0000-0001-9367-0553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Charlotte Marie NiemeyeriD· 2 shared Daniel B. LipkaiD· 2 shared Miriam ErlacheriD· 2 shared Albert Catala· 1 shared Alexandra Emilia SchlaakiD· 1 shared Anna DolnikiD· 1 shared Anna Lena Stippel· 1 shared Bertram BengschiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Charlotte Marie NiemeyerORCID

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2 papers

Recent·Most cited

Hierarchical classification of hematologic malignancies using epigenetic and genetic information

Maximilian Schönung, Melissa Türe, Panna Lajer, Simon Renders, Tobias Rausch, Til L. Steinicke, Anna Dolnik, Eric Sträng, Meghana S. Oak, Jessica Heilmann, K Roth, Lena Katzenstein, Christian Rohde, Etienne Sollier, Peter Horak, , Daniel B. Lipka

The paper develops a hierarchical classification framework combining epigenetic and genetic data with machine learning to improve diagnosis and risk stratification in hematologic malignancies.

bioRxiv · Jul 3, 2026 · PreprintCancer Biology

Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signaling

Jovana Rajak, Ke Meng, Anna Lena Stippel, Jun Wang, Naile Koleci, Sheila Bohler, Alexandra Emilia Schlaak, Hui Xiao, Lukas M. Braun, Riccardo Masetti, Robert Zeiser, Christian Flotho, Daniel B. Lipka, Charlotte Marie Niemeyer, Luciana Hannibal, , Miriam Erlacher

This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.

bioRxiv · Oct 1, 2025 · PreprintCancer Biology