Alveolar Cytochrome P450 Mediates Butylated Hydroxytoluene-Induced Electrophilic Injury and Apoptosis
Michael T. Forrester, Katherine Harbaugh, Naoya Miyashita…·Purushothama Rao Tata
The paper identifies CYP2B10 as the enzyme that activates BHT into a toxic quinone methide, leading to apoptosis and lung damage in mice.