Alveolar Cytochrome P450 Mediates Butylated Hydroxytoluene-Induced Electrophilic Injury and Apoptosis
Michael T. Forrester, Katherine Harbaugh, Naoya Miyashita, Kyoshiro Tsuge, Rhianna E. Lee, Jeremy M. Morowitz, Aleksandra Tata, Robert M. Tighe, Matthew W. Foster, Christine Elissa Eyler, Purushothama Rao Tata
The paper identifies CYP2B10 as the enzyme that activates BHT into a toxic quinone methide, leading to apoptosis and lung damage in mice.
bioRxiv · Sep 11, 2026 · PreprintMolecular Biology