Aleksandra Tata

This study identifies PDGFA-expressing alveolar type 1 cells as a tonic niche organizer that maintains alveolar homeostasis by restraining fibroblast activation and promoting tissue repair.

The paper identifies CYP2B10 as the enzyme that activates BHT into a toxic quinone methide, leading to apoptosis and lung damage in mice.

The paper identifies TP53 activation in alveolar epithelial cells as a driver of cell extrusion and tissue remodeling in IPF through bidirectional lineage plasticity.

This study shows that a bleomycin-induced lung injury model in ferrets shares key pathophysiological, cellular, and molecular features with human idiopathic pulmonary fibrosis, suggesting its use for IPF research.

The paper identifies mechanoenhancers that regulate transcription in response to matrix stiffness and shows their potential for reprogramming cellular responses to mechanical cues.

The paper identifies Cdh4+ dermal fibroblasts in pregnant mice that convert mechanical signals to chemical signals to promote epidermal stem cell proliferation during skin expansion.

This study reveals how persistent intracellular bacterial macromolecules in mucosal epithelial cells drive inflammatory signaling, offering new insights into microbial-host interactions and their potential impact on inflammatory disease treatment and drug efficacy.

The paper introduces Acyl-Trap, a modified suspension trap assay for detecting and quantifying S-acylated proteins with low input, and identifies new S-acylation sites in mouse brain.