A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling
Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Chérine Bechara, Hana Plešingerová, Ondřej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybeľ, Tereza Cihalova, Marek Kravec, , Vı́tězslav Bryja
The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.
bioRxiv · Sep 10, 2025 · PreprintMolecular Biology