Chérine Bechara

Distinct atypical chemokine receptor 1 determinants underlie bacterial toxins recognition and pore formation

This study identifies distinct determinants of ACKR1 recognition by bacterial toxins, revealing a two-step mechanism involving sulfotyrosine binding and extracellular vestibule interaction.

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

This study investigates DAF-12 interactions with transcriptional coactivators in parasitic nematodes using structural and bioinformatic approaches, revealing conserved and nematode-specific mechanisms of coactivator recruitment.

Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential

This study identifies Ephrin B1 as a key mediator of CXCR4 tumorigenic signaling by promoting its intracellular localization and inhibiting surface expression and signaling.

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

This study uses inverse agonistic nanobodies to reveal constitutive activity of ACKR3, showing it drives non-canonical signaling and basal cell motility, suggesting therapeutic potential.

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

TOPOVIBL function in meiotic DSB formation: new insights from its biochemical and structural characterization.

This study characterizes the structure and function of TOPOVIBL, a subunit of the TOPOVIL complex involved in meiotic DSB formation, revealing its DNA interaction properties and dynamic conformation.