Vı́tězslav Bryja

SorCS2 controls Wnt signaling homeostasis during neurodevelopment by regulating Ror2 activity and trafficking

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

NOTCH1-specific phosphorylation of S1970 by Casein Kinase 1 is required for NOTCH1 transcriptional competence and signaling activity in vivo

This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

Proximity interactomics identifies RAI14, EPHA2 and PHACTR4 as essential components of Wnt/planar cell polarity pathway in vertebrates

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

Sex differences and risk factors for bleeding in Alagille syndrome

The paper identifies sex differences in bleeding risk and explores non-invasive vascular analysis in Alagille syndrome using mouse models and retinography.

LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters

LuminoCell is an affordable, open-source luminometer platform for real-time monitoring of in-cell luciferase activity in various biological assays.

A cellular and spatial map of the choroid plexus across brain ventricles and ages

This study constructs a single-cell and spatial atlas of the choroid plexus in developing and adult mice, revealing cell types, regional gene expression, and cell-cell interactions.

MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus

This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.