Author

Tomáš Gybeľ

Masaryk UniversityORCID 0000-0002-5244-1524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:statistical model· 1 Organism:Xenopus· 1

Frequent Co-Authors

Konstantinos TripsianesiD· 3 shared Vı́tězslav BryjaiD· 3 shared David PotěšiliD· 2 shared Kristína GömöryováiD· 2 shared Miroslav MickaiD· 2 shared Ondřej ŠedoiD· 2 shared Sara BolognaiD· 2 shared Tereza CihalovaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Konstantinos TripsianesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 10, 2026

Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway

Tomáš Gybeľ, Kristína Gömöryová, Jana Coufalová…·Vı́tězslav Bryja

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

DOI 10.64898/2026.09.08.750032

humanproteomics

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Cell BiologybioRxivPreprintMay 7, 2026

NOTCH1-specific phosphorylation of S1970 by Casein Kinase 1 is required for NOTCH1 transcriptional competence and signaling activity in vivo

Fabio Turetti, Lorena Agostini Maia, Hana Hajsmanova…·Jan Mašek

This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.

DOI 10.64898/2026.05.05.722849

Xenopusproteomics

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Molecular BiologybioRxivPreprintSep 10, 2025

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

Miroslav Micka, Jitender Kumar, Petra Paclíková…·Vı́tězslav Bryja

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

DOI 10.1101/2025.09.10.675378

statistical modelexperimental assay

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