Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway
Tomáš Gybeľ, Kristína Gömöryová, Jana Coufalová, Tereza Cihalova, Sara Bologna, Miroslav Micka, Ranjani Sri Ganji, David Potěšil, Ondřej Šedo, Tomasz Witold Radaszkiewicz, Zbyněk Zdráhal, Konstantinos Tripsianes, Gopal P. Sapkota, Vı́tězslav Bryja
This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.
bioRxiv · Sep 10, 2026 · PreprintCell Biology