Author

Ondřej Šedo

Central European Institute of Technology – Masaryk UniversityORCID 0000-0002-5091-2978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Zbyněk ZdráhaliD· 3 shared David PotěšiliD· 2 shared Konstantinos TripsianesiD· 2 shared Kristína GömöryováiD· 2 shared Miroslav MickaiD· 2 shared Sara BolognaiD· 2 shared Tereza CihalovaiD· 2 shared Tomáš GybeľiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

Zbyněk ZdráhalORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular mechanisms behind the functional (non)redundancy of CK1 paralogs in the Wnt pathway

Tomáš Gybeľ, Kristína Gömöryová, Jana Coufalová, Tereza Cihalova, Sara Bologna, Miroslav Micka, Ranjani Sri Ganji, David Potěšil, Ondřej Šedo, Tomasz Witold Radaszkiewicz, Zbyněk Zdráhal, Konstantinos Tripsianes, Gopal P. Sapkota, Vı́tězslav Bryja

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

bioRxiv · Sep 10, 2026 · PreprintCell Biology

Enhanced RNA Formation Under Amine-Rich Local Atmospheres from 2',3'- Cyclic Nucleotides

Almuth Schmid, Aleš Kovářík, Jara Hintz, Sreekar Wunnava, Jan Palacký, Miroslav Krepl, Ondřej Šedo, Štěpán Havel, Katarzyna Anna Ślepokura, Jiřı́ Šponer, Peter Mojzeš, Christof Bernhard Mast, Zbyněk Zdráhal, Dieter Braun, Judit E. Šponer

This study shows that ammonium and alkylammonium counterions enhance RNA polymerization from 2,3-cyclic nucleotides under dry, geologically plausible conditions.

bioRxiv · Mar 25, 2026 · PreprintBiochemistry

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Chérine Bechara, Hana Plešingerová, Ondřej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybeľ, Tereza Cihalova, Marek Kravec, , Vı́tězslav Bryja

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

bioRxiv · Sep 10, 2025 · PreprintMolecular Biology