Eliseo Papa

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

This paper introduces AlphaProtein Novo, a machine-learning pipeline for de novo enzyme design that outperforms natural sequence mining in creating enzymes for new-to-nature chemistry and substrates.

Biological Insights Knowledge Graph: an integrated knowledge graph to support drug development

The paper introduces a knowledge graph for drug development that integrates data from multiple sources and supports various tasks through customizable graph projections and machine learning models.

Open Targets Genetics: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

The paper presents an open resource for fine-mapping and gene prioritization at GWAS loci, identifying causal variants and genes and improving drug target identification.

Designing an intuitive web application for drug discovery scientists

The paper describes the design of an intuitive web application for drug discovery scientists to improve data utilization and research advancement.