Selective miniprotein inhibitors of Aurora-A kinase designed using interaction-motif scaffolding
Jennifer A. Miles, Bob Schiffrin, James W. Holder, Emily J. Wallis, Iain W. Manfield, Sean Anthony Burnap, Weston B. Struwe, Fanni V. Gergely, Richard W. Bayliss
The paper designs and tests miniprotein inhibitors of Aurora-A kinase using structure-guided protein design, achieving high potency and selectivity over Aurora-B.
bioRxiv · Jul 13, 2026 · PreprintMolecular Biology