Author

Bob Schiffrin

University of LeedsORCID 0000-0002-1670-7356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Joel A. CrossleyiD· 2 shared Alexander N. KulakiD· 1 shared Antonio N. CalabreseiD· 1 shared Chalmers Chi Cheng ChauiD· 1 shared Emily J. ByrdiD· 1 shared Emily J. WallisiD· 1 shared Emma L. NorgateiD· 1 shared Fanni V. GergelyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Joel A. CrossleyORCID

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Author profile →

3 papers

Recent·Most cited

FENNEC: photon-level deep learning for classifying bursts in diffusion-based single-molecule FRET

Bob Schiffrin, Joel A. Crossley

FENNEC classifies bursts in diffusion-based smFRET data into conformational dynamics and photophysical artefacts using simulated data, without requiring labeled experimental data.

bioRxiv · Jul 16, 2026 · PreprintBiophysics

Selective miniprotein inhibitors of Aurora-A kinase designed using interaction-motif scaffolding

Jennifer A. Miles, Bob Schiffrin, James W. Holder, Emily J. Wallis, Iain W. Manfield, Sean Anthony Burnap, Weston B. Struwe, Fanni V. Gergely, Richard W. Bayliss

The paper designs and tests miniprotein inhibitors of Aurora-A kinase using structure-guided protein design, achieving high potency and selectivity over Aurora-B.

bioRxiv · Jul 13, 2026 · PreprintMolecular Biology

Buffer-dependent conformational dynamics of α-synuclein revealed by nanopipette electrospray ionisation ion mobility mass spectrometry

Emily J. Byrd, Emma L. Norgate, Joel A. Crossley, Chalmers Chi Cheng Chau, Bob Schiffrin, Alexander N. Kulak, Sheena E. Radford, Paolo Actis, Antonio N. Calabrese, Frank Sobott

This study uses nanopipette electrospray ionisation ion mobility mass spectrometry to investigate how buffer conditions affect α-synuclein conformational dynamics.

bioRxiv · Aug 19, 2025 · PreprintBiophysics