Iain W. Manfield

The paper uses iPALM to determine the 3D organisation of three proteins in cardiac muscle Z-discs, revealing differences in their arrangement.

The paper designs and tests miniprotein inhibitors of Aurora-A kinase using structure-guided protein design, achieving high potency and selectivity over Aurora-B.

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

The paper identifies structurally diverse callose/β-1,3-glucans in plant cell wall microdomains and reveals their interactions with xyloglucan.