The role of islet lipid composition remodeling in regulation of beta-cell death via ADP-ribosyl-acceptor glycohydrolase ARH3 signaling in insulitis
Ernesto Satoshi Nakayasu, Cailin S. Deiter, Jennifer E Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Yi Cui, Carrie Nicora, Farooq Syed, Jonas Juan-Mateu, Raghavendra G. Mirmira, Carmella Evans‐Molina, Decio Laks Eizirik, Bobbie‐Jo Webb‐Robertson, Kristin Burnum-Johnson, , Charles K. Ansong
The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.
bioRxiv · Mar 23, 2020 · PreprintSystems Biology