Pedro Henrique Papotto

This study identifies BATF3 as a critical regulator of innate-like γδ T cell homeostasis, function, and tissue distribution, revealing its role in survival, IL-17 production, and immune responses.

The paper generates a Ym1 deficient mouse using CRISPR-Cas9 in CB6 embryos and validates the absence of Ym1 protein without affecting related chitinase genes.

The paper identifies miR-122-5p and miR-1247 as regulators of Th17 and Th1 cell functions in autoimmune inflammation, affecting EAE severity.

This study shows that dermal gamma delta T cells migrate from the skin to the lungs during Nippostrongylus brasiliensis infection, balancing IL-17 and IFN-gamma responses to prevent lung damage.