Tara E. Sutherland

The paper uses imaging mass cytometry to analyze ECM composition in mouse models of allergic airway inflammation, identifying distinct matrix environments associated with different cell types and tissue regions.

This study shows that blocking CD44, a hyaluronan receptor, reduces inflammation and improves survival in mice infected with SARS-CoV-2.

The paper generates a Ym1 deficient mouse using CRISPR-Cas9 in CB6 embryos and validates the absence of Ym1 protein without affecting related chitinase genes.

Mantpy is a framework for analyzing the extracellular matrix in spatial proteomics by representing it as spatial graphs and integrating it with cell data for joint analysis.