Author

Brian H. K. Chan

University of ManchesterORCID 0000-0002-9451-4621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandre BenedettoiD· 1 shared Catherine AuiD· 1 shared David GemsiD· 1 shared David R. WithersiD· 1 shared Faith Denny· 1 shared Filipe CabreiroiD· 1 shared Georgia E. BaldwiniD· 1 shared Hairuo DangiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

Alexandre BenedettoORCID

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2 papers

Recent·Most cited

Migratory dermal gamma delta T cells determine the balance between lung immunity and tissue damage during Nippostrongylus brasiliensis infection

Pedro Henrique Papotto, James E Parkinson, Brian H. K. Chan, I‐Hsuan Lin, Georgia E. Baldwin, Faith Denny, Lili Zhang, Rebecca J. Dodd, Stella T. Pearson, Natalie Fischhaber, Joanne Elizabeth Konkel, David R. Withers, Matthew R. Hepworth, Judith E. Allen

This study shows that dermal gamma delta T cells migrate from the skin to the lungs during Nippostrongylus brasiliensis infection, balancing IL-17 and IFN-gamma responses to prevent lung damage.

bioRxiv · Jan 7, 2025 · PreprintImmunology

LFASS: Label-Free Automated Survival Scoring for High-Throughput Nematode Assays

Alexandre Benedetto, Timothée Bambade, Catherine Au, Jennifer M. A. Tullet, Jennifer L. Monkhouse, Hairuo Dang, Kalina Cetnar, Brian H. K. Chan, Filipe Cabreiro, David Gems

The paper introduces a label-free automated method to score nematode survival in high-throughput assays and finds an autophagy-dependent increase in acute stress resistance in early adulthood.

Aging Cell · Jul 16, 2019Peer-reviewedGenetics