APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells
Sarah E. V. Richards, John T. Demirs, Sandra Jose…·Sha-Mei Liao
This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.