Jacek Stępniewski

This study investigates miR-378a's role in cardiomyocyte metabolism, mitochondrial function, and angiogenic signaling, showing its impact on cardiac performance and limited therapeutic benefit from overexpression.

This study shows that laminin-α2 secreted by muscle stem cells is critical for their expansion and regeneration, and its loss leads to muscle stem cell dysfunction in LAMA2-related muscular dystrophy.

The paper uses hiPSCs to study DMD, finding preserved cardiac dystrophin but reduced skeletal muscle dystrophin and cardiac Dp116 expression.