Author

Erin C. Hedges

King's College LondonORCID 0000-0002-2519-9824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Marc‐David RueppiD· 2 shared Niamh Louise O’BrieniD· 2 shared Adrian M. IsaacsiD· 1 shared Alexander J. CammackiD· 1 shared Alfredo IacoangeliiD· 1 shared Ali Raza Awan· 1 shared Alish PalmosiD· 1 shared Chloe L Fisher-Ward· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Marc‐David RueppORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 12, 2025

CRISPR/Cas9-mediated generation of a de novo C9ORF72 knock-in isogenic iPSC cell bank to model ALS and FTD

Niamh Louise O’Brien, Erin C. Hedges, R. Nair…·Sarah Mizielinska

The paper generates isogenic iPSC lines with a C9ORF72 G4C2 repeat expansion to model ALS and FTD, showing both loss- and gain-of-function pathologies.

DOI 10.1101/2025.11.12.687564

humanexperimental assay

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NeuroscienceNature CommunicationsPeer-reviewedMay 19, 2025

Single-cell RNA sequencing across isogenic FUS and TARDBP ALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons.

Christoph Schweingruber, Jik Nijssen, Jonas Mechtersheimer…·Eva Hedlund

This study uses single-cell RNA sequencing to identify shared mitochondrial dysfunction in motor neurons across FUS and TARDBP ALS mutations, suggesting common toxic mechanisms.

41 citationstop 1%

humanscRNA-seq

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NeuroscienceNeuropsychopharmacologyPeer-reviewedSep 13, 2020

The impact of telomere shortening on human hippocampal neurogenesis: Implications for cognitive function and psychiatric disorder risk

Alish Palmos, Rodrigo R. R. Duarte, Demelza M. Smeeth…·Timothy R. Powell

This study models telomere shortening in human hippocampal progenitor cells and links it to reduced neurogenesis, cognitive impairment, and psychiatric disorder risk.

36 citations

humanbulk RNA-seq

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