Christoph Schweingruber

This study investigates the role of beta2-microglobulin and HLA in motor neuron vulnerability in ALS, finding dynamic regulation but not major disease modification.

The paper develops U7 snRNA therapeutics to correct TDP-43-dependent mis-splicing in ALS, restoring gene expression and neuronal function in human iPSC-derived neurons.

This study uses single-cell RNA sequencing to identify shared mitochondrial dysfunction in motor neurons across FUS and TARDBP ALS mutations, suggesting common toxic mechanisms.

The paper analyzes single-nucleus RNA-seq data from human spinal cord neurons, identifies motor neurons as rare, and highlights discrepancies with a prior study due to potential misclassification of cholinergic debris.

This study uses LCM-seq to analyze transcriptional changes in SMA, identifying cell-type specific adaptations that explain resistance in ocular motor neurons.

This study generates oculomotor neurons from mouse stem cells and shows they are more resilient to ALS-like toxicity than spinal motor neurons.