BiochemistryCell DiscoveryPeer-reviewed
Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs
Canrong Wu, Chao Zhang, Sanshan Jin…·H. Eric Xu
This study presents cryo-EM structures of hURAT1 bound with anti-gout drugs and uric acid, revealing transport mechanisms and drug inhibition.