Author

Heng Zhang

Chinese Academy of SciencesORCID 0000-0002-9441-8277Unclaimed ORCID profile · follow to get notified of new preprints

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Heng Zhang2 papers · Sichuan University

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Canrong WuiD· 2 shared H. Eric XuiD· 2 shared Jiuyin XuiD· 2 shared Wen HuiD· 2 shared Xinheng HeiD· 2 shared Antao DaiiD· 1 shared Chao ZhangiD· 1 shared Dehua YangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Canrong WuORCID

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2 papers

Recent·Most cited

Structural Insights into Selective and Dual Antagonism of EP2 and EP4 Prostaglandin Receptors

Yanli Wu, Heng Zhang, Jiuyin Xu, Kai Wu, Wen Hu, Xinheng He, Gaoming Wang, Canrong Wu, H. Eric Xu

The paper presents cryo-EM structures of EP2 and EP4 receptors with antagonists, revealing structural differences that explain selectivity and binding modes.

The EMBO Journal · Oct 29, 2025Peer-reviewedBiochemistry

Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs

Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Ming‐Wei Wang, Yi Jiang, Dehua Yang, H. Eric Xu

This study presents cryo-EM structures of hURAT1 bound with anti-gout drugs and uric acid, revealing transport mechanisms and drug inhibition.

Cell Discovery · Apr 1, 2025Peer-reviewedBiochemistry