Sujit Silas Armstrong Suthahar

This paper generates synthetic scRNA-seq-like transcriptomes from bulk RNA-seq data using a cycleGAN approach to bridge the resolution gap between bulk and single-cell transcriptomics.

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

The paper screens 133 chemicals for reproductive toxicity using C. elegans assays and compares results with ToxCast data, identifying 13 toxicants including QACs.