Daniel G. Chen

This study shows EBV reprograms B cells in COVID-19 patients, leading to autoimmune-like features such as autoantibodies and dysregulated lipid profiles, similar to lupus and multiple sclerosis.

SpaceBender denoises spatial transcriptomics data by leveraging spatial information, improving biological signal clarity and statistical significance in simulations and real tissues.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

scanCT identifies disease-associated genomic feature groups using a tree-based framework applied to single-cell multi-omics COVID-19 data, revealing interpretable marker combinations.

The paper introduces Tarpon, a generative AI model that synthesizes TCR atlases to uncover T cell behavior patterns and cross-dataset mappings of T cell states.

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

APMAT analysis links CD8 T cell receptors, cognate antigens, and T cell phenotype/persistence using integrated experimental-computational methods.