LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK
Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy B. Kang, Geming Lu, Yate‐Ching Yuan, Hung-Ping Shih, S. Bhattacharya, Sangeeta Dhawan, Adolfo Garcı́a-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada
This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.
Molecular Metabolism · Jan 7, 2025Peer-reviewedPhysiology