Hung-Ping Shih

The paper investigates how developmental DNA damage responses in α- and β-cells contribute to their differential susceptibility to diabetes, showing β-cells have higher DNA damage vulnerability and repair efficiency.

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

The paper shows that ECM and cell-cell adhesion coordinate to regulate islet aggregation, architecture, and functional maturation during development.

This study identifies DNA methylation as a mechanism restricting TH+ β-cell subpopulation in pancreatic islets, showing its role in β-cell heterogeneity and identity maintenance.

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.

The paper identifies miRNAs that promote cell cycle exit and differentiation of human pancreatic endocrine cells through regulatory networks.

The paper shows LSD1-mediated enhancer silencing limits RA signaling duration during endocrine cell development by suppressing persistent enhancer activity.