Author

Mary Kristen Demoruelle

University of Colorado AnschutzORCID 0000-0002-2563-5155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Ashley G. Asamoah· 2 shared Cate SpeakeiD· 2 shared David L. BoyleiD· 2 shared Fan ZhangiD· 2 shared Gary S. FiresteiniD· 2 shared Jane Hoyt BuckneriD· 2 shared Julian ReadingiD· 2 shared Kevin D. DeaneiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Ashley G. Asamoah

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Author profile →

2 papers

Recent·Most cited

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

Ziyuan He, Marla C. Glass, Pravina Venkatesan, Marie L. Feser, Leander Lazaro, Lauren Y. Okada, Nhung T. T. Tran, Yudong D. He, Samir Rachid Zaim, Christy Bennett, Padmapriyadarshini Ravisankar, Elisabeth M. Dornisch, Alexandra Ferrannini, Najeeb A. Arishi, Ashley G. Asamoah, , Mark A. K. Gillespie

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

Science Translational Medicine · Sep 24, 2025Peer-reviewedImmunology

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

Cong Liu, Z. Audrey Wang, Edward B. Prideaux, David L. Boyle, Katherine Nguyen, Vlad Tsaltskan, Amy Westermann, Andrea E. Ochoa, Kevin D. Deane, Marie L. Feser, Mary Kristen Demoruelle, Kristine A. Kuhn, Vernon Michael Holers, Fan Zhang, Ashley G. Asamoah, , Wei Wang

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

bioRxiv · Feb 8, 2025 · PreprintSystems Biology