Jane Hoyt Buckner

Heterogeneity of HCMV-Specific CD8+ T Cells is Established Early in Infection, Clonally Encoded, and Stable Over Time

The paper tracks CMV-specific CD8+ T cells over time to show that clonal diversity and phenotypes are established early and remain stable during chronic infection.

Deep immune profiling of the peripheral blood reveals disease- and sex-associated immune cell signatures in patients with systemic sclerosis

The paper identifies sex-associated immune cell signatures in systemic sclerosis patients using high-dimensional immune profiling of peripheral blood mononuclear cells.

Epigenetic trajectory predicts development of clinical rheumatoid arthritis in ACPA+ individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)

The paper identifies epigenetic trajectories in ACPA+ individuals that predict RA development, showing dynamic methylation changes in Pre-RA compared to stable methylomes in non-converters and controls.

Serum proteomics reveals distinct phenotypic signatures to IL-6 blockade between two immunotherapies

This study compares the effects of two IL-6 inhibitors on serum extracellular vesicles using proteomics, finding distinct protein pathway alterations.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells.

The paper identifies 545 expression-modulating variants in CD4+ T cells linked to autoimmune diseases and shows they regulate genes in a lymphocyte activation network.

Reduced function of the adaptor SH2B3 promotes T1D via altered γc cytokine-regulated, T cell intrinsic immune tolerance

This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis

The paper identifies biomarkers and genetic variants associated with COVID-19 linked secondary hemophagocytic lymphohistiocytosis (sHLH) and links them to immune system defects.

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

The paper identifies shifts in isoform usage in Tregs associated with Type 1 Diabetes by comparing gene expression between cases and controls.

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

The paper investigates how HLA alleles influence TCR CDR3 composition and finds strong associations between HLA risk alleles and specific CDR3 amino acid features linked to autoimmune diseases.

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

This study identifies causal variants, cells, genes, and drug targets for type 1 diabetes using large-scale genetic and functional genomic analyses.