Loukia Parisiadou

This study shows that LRRK2 regulates synaptic function by modulating actin cytoskeletal dynamics through BDNF signaling in neurons.

This study identifies LRRK2's role in impairing dopamine axon release sites in Parkinson's disease, leading to reduced dopamine release and synaptic dysfunction.

The paper identifies molecular subtypes of midbrain dopamine neurons, maps their spatial distribution, and shows transcriptional changes in a Parkinson's disease model.

This study shows that LRRK2 kinase mediates haloperidol-induced motor side effects in striatal neurons, suggesting LRRK2 as a target to reduce antipsychotic side effects.

This study shows that pathogenic LRRK2 mutations cause age-dependent and region-specific deficits in ciliation, innervation, and viability of cholinergic neurons in mice.

This study investigates how pathogenic LRRK2 mutations affect striatal physiology in mice, finding that R1441C causes motor learning deficits rescued by a kinase inhibitor, while G2019S does not.

This paper identifies a genetic variant associated with primary non-response to anti-TNFα therapy in IBD patients and links it to increased TNF secretion through autophagy mechanisms.

This study investigates how LRRK2 mutations affect synaptic structure and function in striatal neurons, revealing pathway-specific changes that may contribute to Parkinson's disease.