Daniel A. Dombeck

The paper maps dopamine subtype projections in the basal ganglia to reveal spatially distinct domains and their correlation with striatal neuron subclasses and cortical inputs.

This study identifies LRRK2's role in impairing dopamine axon release sites in Parkinson's disease, leading to reduced dopamine release and synaptic dysfunction.

The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.

The paper identifies distinct neural subnetworks in neocortex and entorhinal cortex for interval timing, spatial navigation, and reward using virtual reality and calcium imaging.

The paper shows that Fos-expressing neurons in the hippocampus encode environmental boundaries stably across days in novel environments.

The paper shows that the lateral and medial entorhinal cortices map olfactory and visual spaces separately, suggesting the hippocampus combines these maps into a multisensory cognitive map.

The paper identifies molecular subtypes of midbrain dopamine neurons, maps their spatial distribution, and shows transcriptional changes in a Parkinson's disease model.

This study shows that hippocampal representational drift persists in mice even in a stable multisensory virtual environment, with neuronal excitability influencing drift rates.

This study investigates how reward location variability affects hippocampal spatial representations by inducing reorganization in place cell populations under different uncertainty conditions.

The paper identifies LEC subpopulations in mice that represent experiential epochs around reward during navigation, showing their role in encoding reward-related information.

The paper identifies three genetic dopamine subtypes in the substantia nigra pars compacta, each with distinct functional responses to rewards, aversive stimuli, and movement, showing strong correlation between soma and axon signaling within subtypes.

The paper shows that somatic and axonal signaling in dopamine neurons of behaving mice are correlated, challenging previous assumptions about axonal autonomy.

The paper evaluates information theoretic metrics for functional fluorescence data by generating mock traces and applying them to mouse hippocampal calcium imaging data.