Author

Harry S. Xenias

Northwestern UniversityORCID 0000-0002-9502-0973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

C. Savio ChaniD· 4 shared Arin PamukcuiD· 3 shared Brianna L. BerceauiD· 3 shared Qiaoling CuiiD· 3 shared Simina Maria BocaiD· 3 shared Suraj CherianiD· 3 shared Nicholas J. JusticeiD· 2 shared Zachary A. AbecassisiD· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

C. Savio ChanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pathogenic LRRK2 R1441C mutation is associated with striatal alterations

Harry S. Xenias, Chuyu Chen, Shuo Kang, Suraj Cherian, Xiaolei Situ, Bharanidharan Shanmugasundaram, Guoxiang Liu, Giuseppe Scesa, C. Savio Chan, Loukia Parisiadou

This study investigates how pathogenic LRRK2 mutations affect striatal physiology in mice, finding that R1441C causes motor learning deficits rescued by a kinase inhibitor, while G2019S does not.

Communications Biology · Nov 10, 2022Peer-reviewedNeuroscience

Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns

Qiaoling Cui, Arin Pamukcu, Suraj Cherian, Isaac Y. M. Chang, Brianna L. Berceau, Harry S. Xenias, Matthew H. Higgs, Shivakumar Rajamanickam, Yi Chen, Xixun Du, Yu Zhang, Hayley E. McMorrow, Zachary A. Abecassis, Simina Maria Boca, Nicholas J. Justice, , C. Savio Chan

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

Journal of Neuroscience · Mar 17, 2021Peer-reviewedNeuroscience

Parvalbumin+ and Npas1+ Pallidal Neurons Have Distinct Circuit Topology and Function

Arin Pamukcu, Qiaoling Cui, Harry S. Xenias, Brianna L. Berceau, Elizabeth C. Augustine, Isabel Fan, Saivasudha Chalasani, Adam W. Hantman, Talia N. Lerner, Simina Maria Boca, C. Savio Chan

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.

Journal of Neuroscience · Aug 31, 2020Peer-reviewedNeuroscience

Npas1+-Nkx2.1+ Neurons Form A Unique Pallidal Neuron Subclass

Zachary A. Abecassis, Brianna L. Berceau, Phyo H. Win, Daniela García, Harry S. Xenias, Qiaoling Cui, Arin Pamukcu, Suraj Cherian, Vivian M. Hernández, Uree Chon, Byung Kook Lim, Nicholas J. Justice, Rajeshwar B. Awatramani, Yongsoo Kim, Bryan M. Hooks, , C. Savio Chan

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.

Journal of Neuroscience · Dec 6, 2019Peer-reviewedNeuroscience