Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming Chemoresistance
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick B. Walter, Mohsen Akbari
The paper identifies metabolic vulnerabilities in TMZ-resistant glioblastoma cells, showing that iron reduction enhances the efficacy of TMZ through mechanisms involving Hif1, autophagy, and ROS.
Advanced Science · Apr 26, 2025Peer-reviewedCancer Biology