Adam E. Mullick

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

This study shows that Angiotensin II exacerbates mitral valve and left atrial pathology in Fbn1C1041G/+ mice, while AGT inhibition does not alter the phenotype.

This study shows that reducing MLKL in mice prevents diet-induced obesity and improves insulin signaling in fat cells.

This study shows that intermittent fasting improves systemic metabolism regardless of ketogenesis but has sex-specific hepatic benefits requiring ketogenesis in mice.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

This study investigates whether renin-angiotensin inhibition affects ACE2 and TMPRSS2 expression in mice, finding no changes in ACE2 but a decrease in TMPRSS2 in lungs with AGT depletion.