Deepika Dayal Mathur

Single-nucleus transcriptome-wide association study of human brain disorders

This study performs a single-nucleus transcriptome-wide association study to identify gene-trait associations in brain disorders, revealing cell-type-specific genetic regulation and ancestry-specific patterns.

Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human Brain

The paper constructs a single-nucleus atlas of genetic regulation in the human brain, identifying cell-type-specific regulatory effects and disease-associated genes.

Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease

The paper profiles human myeloid cells across aging and Alzheimer's disease, identifies AD-associated changes, and links GPNMB to neuroprotection via TREM2.

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases

The paper constructs a single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex across neurodegenerative and neuropsychiatric diseases, revealing shared and distinct molecular mechanisms.

PrePCI: A structure- and chemical similarity-informed database of predicted protein compound interactions

PrePCI predicts protein-compound interactions using structural and chemical similarity, providing a database of over 5 billion interactions with associated probabilities.

Detecting and Adjusting for Hidden Biases due to Phenotype Misclassification in Genome-Wide Association Studies

This paper introduces PheMED, a tool to quantify effect size dilution in GWAS due to phenotypic misclassification, and demonstrates its applications in improving meta-analysis.

SAPdb: A database of nanostructures formed by self-assembly of short peptides

SAPdb is a database of experimentally validated peptide nanostructures formed by self-assembly, providing information on chemical modifications, nanostructure types, and experimental conditions.