ImmunologyCancer DiscoveryPeer-reviewed
An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer
Wenyan Xie, Xin Yu, Qingxin Yang…·Hong Jiang
This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.
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