Author

Hubing Shi

Sichuan UniversityORCID 0000-0002-2926-3440Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:mechanistic / dynamical model· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Hao KongiD· 2 shared Hong JiangiD· 2 shared Lang CheniD· 2 shared Nengwen KeiD· 2 shared Panpan MaiD· 2 shared Qiang WeiiD· 2 shared Qingxin YangiD· 2 shared Xiangji WuiD· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Hao KongORCID

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3 papers

Recent·Most cited

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer

Wenyan Xie, Xin Yu, Qingxin Yang, Nengwen Ke, Ping Wang, Hao Kong, Xiangji Wu, Panpan Ma, Lang Chen, Jie Yang, Xiuqin Feng, Yuan Wang, Hubing Shi, Lu Chen, Yunhua Liu, , Hong Jiang

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

Cancer Discovery · May 8, 2025Peer-reviewedImmunology

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

Hao Kong, Xiangji Wu, Qingxin Yang, Qian Sun, Xin Yu, Yu Dai, Chun-Wei George Wu, Dai Xie, Lang Chen, Panpan Ma, Siqi Dai, Chong Chen, Peng Mi, Xiaodong Feng, Yong Li Peng, , Hong Jiang

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

bioRxiv · Jul 24, 2024 · PreprintImmunology

AIDE: annotation-assisted isoform discovery with high precision

Wei Vivian Li, Shan Li, Xin Tong, Ling Deng, Hubing Shi, Jingyi Jessica Li

AIDE improves mRNA isoform discovery by using annotation to enhance precision and reduce errors in RNA-seq data analysis.

Genome Research · Dec 1, 2019Peer-reviewedBioinformatics