Author

Patrick T. Caswell

Manchester Academic Health Science CentreORCID 0000-0002-2633-2324Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jakub GemperleiD· 3 shared Christine MénageriD· 2 shared Domenik Liße· 2 shared Emilie SecretiD· 2 shared Jacob PiehleriD· 2 shared Marie KappeniD· 2 shared Mathieu CoppeyiD· 2 shared Angelica Castaneda· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Jakub GemperleORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 28, 2026

Stromal COL12A1 defines a pro-invasive extracellular matrix niche in appendiceal mucinous neoplasms and pseudomyxoma peritonei

Milly Upton, Raghavendar Thyagaraja Nagaraju, Angelica Castaneda…·PMPnet group

This study identifies stromal COL12A1 as a key component of the extracellular matrix niche that supports invasion in appendiceal mucinous neoplasms and pseudomyxoma peritonei.

DOI 10.64898/2026.10.26.761946

humanproteomics

Cell BiologybioRxivPreprintFeb 4, 2026

Cell-matrix mechanosensing and cellular metabolic demand are linked through SKT and mTORC2

Milan Collins, Lorna E. Young, Emily Goodall…·Tobias Zech

This study identifies SKT as a link between cell-matrix mechanosensing and metabolic regulation through mTORC2, showing its role in PDAC progression.

DOI 10.64898/2026.02.03.702586

humanproteomics

Cancer BiologyScience AdvancesPeer-reviewedJul 4, 2025

Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration

Jakub Gemperle, Domenik Liße, Marie Kappen…·Patrick T. Caswell

The paper uses magnetic micromanipulation to show Rab25 vesicles directly drive F-actin protrusions, enhancing cancer cell invasive migration.

9 citationstop 4%

humanproteomics

Cell BiologyJournal of Cell SciencePeer-reviewedJun 16, 2025

Differential roles of cyclin-CDK1 complexes in cell migration and invasion

Joseph H. R. Hetmanski, Michael J. Jones, Matthew Hartshorn…·Matt Jones

This study identifies distinct roles of cyclinB1-CDK1 and cyclinA2-CDK1 complexes in cell migration and invasion, showing they regulate motility and division independently of cell-cycle phase.

8 citations

experimental assaycell signaling & trafficking

BiophysicsbioRxivPreprintOct 31, 2024

Biofunctional coating of synthetic magnetic nanoparticles enables magnetogenetic control of protein functions inside cells

Marie Kappen, Jakub Gemperle, Emilie Secret…·Jacob Piehler

1 citation

experimental assaycell signaling & trafficking

Molecular BiologyeLifePeer-reviewedMay 30, 2022

DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members

Jakub Gemperle, Thomas S Harrison, Chloe Flett…·Patrick T. Caswell

The paper introduces DExCon, DExogron, and LUXon methods to control endogenous gene expression using CRISPR-Cas9, enabling on-demand activation and analysis of Rab11 family members.

2 citations

humanproteomics