Tobias Zech

This study identifies SKT as a link between cell-matrix mechanosensing and metabolic regulation through mTORC2, showing its role in PDAC progression.

The paper shows that the SxIP motif binds EBH with low affinity, but full interaction requires post-SxIP residues, leading to a nanomolar affinity and enhanced recruitment to microtubule plus ends.

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

This study shows that overexpression of SAS-6 promotes ciliogenesis and cell invasion through YAP/TAZ pathway activation, linked to poor cancer prognosis.