The paper quantifies spatial proteoforms in Alzheimer's disease by analyzing subcellular protein localization and identifies key pathways disrupted in disease progression.

bioRxiv · Jul 4, 2026 · PreprintNeuroscience

Rapid Histone Post-Translational Modification Analysis Using Alternative Proteases and Tandem Mass Tags

Natalie P. Turner, Sabyasachi Baboo, Patrick Garrett, Jolene K. Diedrich, Michal Bajo, Marisa Roberto, John R. Yates

This paper introduces RIPUP, a rapid protease-based workflow for histone PTM analysis, showing improved PTM coverage and quantitative accuracy using TMT labeling and complementary proteases.

Analytical Chemistry · Jun 19, 2026Peer-reviewedBiochemistry

The effects of Alcohol Dependence on the CSF Proteome in Mice: Evidence for Blood-Brain Barrier Dysfunction and Neuroinflammation

Natalie P. Turner, Michal Bajo, Amanda J. Roberts, Marisa Roberto, John R. Yates

This study uses proteomics to compare CSF from alcohol-dependent and non-dependent mice, identifying molecular changes linked to BBB dysfunction and neuroinflammation.

Neurobiology of Disease · Dec 31, 2025Peer-reviewedNeuroscience

CandyCollect: An Open-Microfluidic Device for the Direct Capture and Analysis of Salivary-Extracellular Vesicles

Corinne Pierce, Natalie P. Turner, Ingrid H Robertson, Dakota McMillan, Xiaojing Su, Daniel B. Hatchett, Albert Shin, Olufemi Lijadu, Damon Wing Hey Chan, Sarah Feng, Karen N. Adams, Kezia E. Suryoraharjo, Alana F. Ogata, Erwin Berthier, Sanitta Thongpang, , Lydia Lee Sohn

CandyCollect is a microfluidic device for rapid, non-invasive salivary EV collection and analysis, showing consistent EV capture and concordant protein profiles.

bioRxiv · Oct 9, 2024 · PreprintBioengineering