Aïcha Massrali

Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function

This study compares mono- and bi-allelic NRXN1 mutations in iPSC-derived neurons, showing bi-allelic mutations cause more severe molecular, synaptic, and functional impairments.

Impact of intragenic NRXN1 deletions on early cortical development

This study investigates the impact of NRXN1 intronic deletions on early cortical development using hiPSCs, finding altered isoform expression and dendritic morphology.

Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits

The paper identifies shared epigenetic architecture between autism and autistic traits by analyzing DNA methylation and genetic data across multiple cohorts.